 4-2-3-1
Its been used with Bayern in real life, when Klose has been injured. Its normal at the back with 4 defenders and then two CM-DMs with van Bommel and ze Roberto that arent natural defensive midfielders, but have the advantage of being able to both defend well and most importantly to speed the game up and deliver accurate and fast balls to the 3 attacking midfielders up front that are with Bayern: Schweinsteiger, Ribery Sosa(Altintop).
Now this is important! These 3 change positions during the game and rip apart their opponents with their creativity, speed and dribblings. The man upfront Toni or Klose are both big lads and can jump and head very well and are physically good enough to cope with more than just one defender. They play quick tempo with short passing. It looks effective in reality as Bayern have won 3 out of 3 in the lague and have a 10-0 in goals overall.
In FM I would use someone like Gago or Lucas next to someone more physically strong and good at heading, just like Ze Roberto and van Bommel.
Then I would put them to Cm and draw arrows down to the DM position. Then all you need is skillfull attacking-minded midfielders ala Ribery. The last piece is a target striker prefferablly tall and strong with good finishing, and heading. Set him up as target man and dont use a plamaker. | 
